منابع مشابه
Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion.
BACKGROUND Severe, often refractory anemia is characteristic of the myelodysplastic syndrome associated with chromosome 5q31 deletion. We investigated whether lenalidomide (CC5013) could reduce the transfusion requirement and suppress the abnormal 5q31- clone in patients with this disorder. METHODS One hundred forty-eight patients received 10 mg of lenalidomide for 21 days every 4 weeks or da...
متن کاملMyelodysplastic Disorders, 5q-Syndrome
The myelodysplastic syndromes (MDSs) are characterized by ineffective erythropoie‐ sis and progressive cytopenia and ultimately affected patients develop acute myeloid leukemia (AML) or die from advanced bone marrow (BM) failure. Myelodysplastic syndrome (MDS) with isolated del (5q) is a common type of MDS with specific pathological and clinical manifestations including refractory anemia. It is...
متن کاملUnusual clonal evolution involving 5q in a case of myelodysplastic syndrome with deletion 5q 31 treated with lenalidomide.
Lenalidomide is a very active drug in myelodysplastic syndrome with del (5q). We report such a patient treated with this drug who developed unusual complex cytogenetic abnormalities, which were elucidated by multi-FISH and FISH analysis as jumping translocations involving the long arm of chromosome 5, that resulted in an increase of 5q copies. This unusual findings is discussed in the context o...
متن کاملPathophysiology and treatment of the myelodysplastic syndrome with isolated 5q deletion.
Group. Ann N Y Acad Sci. 2005;1054:186-95. 20. LeBoulch Ph and the LentiGlobin clinical trial study group. (Abs) Ninth Cooley’s Anemia Symposium, NY Acad Sci Oct 21-24, 2009. 21. Sadelain M, Boulad F, Lisowki L, Moi P, Riviere I. Stem cell engineering for the treatment of severe hemoglobinopathies.Curr Mol Med. 2008;8(7):690-7. 22. Thein SL, Menzel S. Discovering the genetics underlying foetal ...
متن کاملA Case of Refractory Thrombocytopenia with 5q Deletion: Myelodysplastic Syndrome Mimicking Idiopathic Thrombocytopenic Purpura
Jeonghyun Chang, M.D., Chan-Jeoung Park, M.D., Eul-Ju Seo, M.D., Jung-Hee Lee, M.D., Sang Hyuk Park, M.D., Young-Uk Cho, M.D., and Seongsoo Jang, M.D. Departments of Laboratory Medicine and Internal Medicine, University of Ulsan College of Medicine and Asan Medical Center,Seoul; Department of Laboratory Medicine, Pusan National University School of Medicine, Pusan National University Hospital, ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Indian Journal of Pathology and Microbiology
سال: 2017
ISSN: 0377-4929
DOI: 10.4103/0377-4929.208396